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크로마토그래피 > 분석용 소모품

Glycan Standard & Kits

크로마토그래피 > 분석용 소모품

Glycan Standard & Kits

Specifically formulated reference standards and high-quality reagents that help you benchmark and perform glycan applications using a variety of derivitazation labeling techniques or non-labeling column chemistries on any LC-MS system.

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Waters
HILIC for Released Glycans

Robust LC or LC-MS Analyses of Biotherapeutic Glycoproteins

The analysis of complex N- and 0-linked glycans composed of frequently similar and repeating sugar moieties requires a highly discriminating chromatographic method. Hydrophilic liquid interaction chromatography (HILIC), using UPLC, HPLC, or UHPLC columns containing Waters amide bonded, Ethylene Bridged Hybrid Technology (BEH) particles separates compounds based on differing hydrophilicity.

Released N-Glycan Columns

Waters ACQUITY UPLC and XBridge Glycan BEH Amide 130Å Columns are best suited for the analysis of released, N-labeled glycans using pre-column labeling with 2-AB, 2-AA, or Waters innovative and enabling RapiFluor-MS reagent. Each batch our Glycan BEH Amide 130Å chemistry is specifically QC tested with a complex mixture of 2-AB labeled glycans from a mAb digest to help ensure consistent column performance in validated methods.


The image to the right shows the N-linked glycans from pooled human IgG contain high mannose as well as neutral, and sialylated complex structures. The chromatogram shows 35 minutes of a one hour analysis. This challenging sample includes high mannose, bisecting GlcNAc and sialylated species.

Scalability

Shown to the right is the performance of HILIC glycan columns varying in particle size at the same linear velocity.




담당 부서 : 분석기술사업부 분리분석팀 (02-6190-9841)


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